吉森研究室
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山室さんらの研究成果がPLoS Geneticsに掲載

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原著論文

Wakita M, Takahashi A, Sano O, Loo TM, Imai Y, Narukawa M, Iwata H, Matsudaira T, Kawamoto S, Ohtani N, Yoshimori T, Hara E.

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.
Nat. Commun., 11(1):1935. (2020) Epub 2020 Apr 22. doi: 10.1038/s41467-020-15719-6.

Ikari S, Lu SL, Hao F, Imai K, Araki Y, Yamamoto Y, Tsai CY, Nishiyama Y, Shitan N, Yoshimori T, Otomo T, Noda T.

Starvation-induced autophagy via calcium-dependent TFEB dephosphorylation is suppressed by Shigyakusan.
PLoS One. 15(3):e0230156 (2020) Epub 2020 Mar 5. doi:10.1371/journal.pone.0230156

Matsuda J, Takahashi A, Takabatake Y, Sakai S, Minami S, Yamamoto T, Fujimura R, Namba-Hamano T, Yonishi H, Nakamura J, Kimura T, Kaimori JY, Matsui I, Takahashi M, Nakao M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Yoshimori T, Isaka Y.

Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Autophagy. 1-16 (2020) Epub 2020 Jan 16. doi: 10.1080/15548627.2020.1712107.

Nakashima A, Cheng SB, Ikawa M, Yoshimori T, Huber WJ, Menon R, Huang Z, Fierce J, Padbury JF, Sadovsky Y, Saito S, Sharma S.

Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia.
Autophagy. 1-15(2019) Epub 2019 Dec 26. doi: 10.1080/15548627.2019.1707494.

Unno R, Kawabata T, Taguchi K, Sugino T, Hamamoto S, Ando R, Okada A, Kohri K, Yoshimori T, Yasui T.

Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development.
Autophagy, 1-15. [Epub ahead of print] doi: 10.1080/15548627.2019.1635382.

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