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原著論文

Kakuda K, Ikenaka K, Kuma A, Doi J, Aguirre C, Wang N, Ajiki T, Choong CJ, Kimura Y, Badawy SMM, Shima T, Nakamura S, Baba K, Nagano S, Nagai Y, Yoshimori T, Mochizuki H.

 Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles.

Proc Natl Acad Sci U S A. 121: e2312306120 (2023) doi: 10.1073/pnas.2312306120.

Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S.

HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence.

Proc Natl Acad Sci U S A. 121: e2306454120 (2024) doi: 10.1073/pnas.2306454120.

Ogura M, Kaminishi T, Shima T, Torigata M, Bekku N, Tabata K, Minami S, Nishino K, Nezu A,  Hamasaki M,  Kosako H,  Yoshimori T,  Nakamura S.

Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.

EMBO Rep. 24 :e57300 (2023) . doi: 10.15252/embr.202357300.

Shima T, Ogura M, Matsuda R, Nakamura S, Jin N, Yoshimori T, Kuma A.

The TMEM192-mKeima probe specifically assays lysophagy and reveals its initial steps. J Cell Biol. 222: e202204048 (2023) doi: 10.1083/jcb.202204048.

Tsai CY, Sakakibara S, Kuan YD, Omori H, El Hussien MA, Okuzaki D, Lu SL, Noda T, Tabata K, Nakamura S, Yoshimori T, Kikutani H.

Opposing roles of RUBCN isoforms in autophagy and memory B cell generation. Sci Signal. 16: eade3599. doi: 10.1126/scisignal.ade3599.

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© 2018 T.YOSHIMORI LAB.

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