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原著論文

Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S.

HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence.

Proc Natl Acad Sci U S A. 121: e2306454120 (2024) doi: 10.1073/pnas.2306454120.

PubMed

Kakuda K, Ikenaka K, Kuma A, Doi J, Aguirre C, Wang N, Ajiki T, Choong CJ, Kimura Y, Badawy SMM, Shima T, Nakamura S, Baba K, Nagano S, Nagai Y, Yoshimori T, Mochizuki H.

 Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles.

Proc Natl Acad Sci U S A. 121: e2312306120 (2023) doi: 10.1073/pnas.2312306120.

Pubmed

Shima T, Ogura M, Matsuda R, Nakamura S, Jin N, Yoshimori T, Kuma A.

The TMEM192-mKeima probe specifically assays lysophagy and reveals its initial steps. J Cell Biol. 222: e202204048 (2023) doi: 10.1083/jcb.202204048.

PubMed

Ogura M, Kaminishi T, Shima T, Torigata M, Bekku N, Tabata K, Minami S, Nishino K, Nezu A,  Hamasaki M,  Kosako H,  Yoshimori T,  Nakamura S.

Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.

EMBO Rep. 24 :e57300 (2023) . doi: 10.15252/embr.202357300.

PubMed

Shioda T, Takahashi I, Ikenaka K, Fujita N, Kanki T, Oka T, Mochizuki H, Antebi A, Yoshimori T, Nakamura S.

Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity. Proc. Natl. Acad. Sci. U. S. A. 120: e2221553120 (2023) doi: 10.1073/pnas.2221553120

PubMed

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