吉森研究室 | 大阪大学大学院生命機能研究科細胞内膜動態研究室／医学系研究科遺伝学教室

原著論文

Tabata K, Imai K, Fukuda K, Yamamoto K, Kunugi H, Fujita T, Kaminishi T, Tischer C, Neumann B, Reither S, Verissimo F, Pepperkok R, Yoshimori T, Hamasaki M.

Palmitoylation of ULK1 by ZDHHC13 plays a crucial role in autophagy
Nat Commun. (2024) Aug 21;15(1):7194. doi: 10.1038/s41467-024-51402-w.

PubMed

Yanagawa K, Kuma A, Hamasaki M, Kita S, Yamamuro T, Nishino K, Nakamura S, Omori H, Kaminishi T, Oikawa S, Kato Y, Edahiro R, Kawagoe R, Taniguchi T, Tanaka Y, Shima T, Tabata K, Iwatani M, Bekku N, Hanayama R, Okada Y, Akimoto T, Kosako H, Takahashi A, Shimomura I, Sakata Y, Yoshimori T.

The Rubicon-WIPI axis regulates exosome biogenesis during ageing
Nat Cell Biol. (2024) Sep;26(9):1558-1570. Epub 2024 Aug 22.
doi: 10.1038/s41556-024-01481-0.

PubMed

Kitta S, Kaminishi T, Higashi M, Shima T, Nishino K, Nakamura N, Kosako H, Yoshimori T, Kuma A.

YIPF3 and YIPF4 regulate autophagic turnover of the Golgi apparatus.
EMBO J. (2024) Jul;43(14):2954-2978. Epub 2024 May 31.
doi: 10.1038/s44318-024-00131-3

PubMed

Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S.

HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence.

Proc Natl Acad Sci U S A. 121: e2306454120 (2024) doi: 10.1073/pnas.2306454120.

PubMed

Kakuda K, Ikenaka K, Kuma A, Doi J, Aguirre C, Wang N, Ajiki T, Choong CJ, Kimura Y, Badawy SMM, Shima T, Nakamura S, Baba K, Nagano S, Nagai Y, Yoshimori T, Mochizuki H.

Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles.

Proc Natl Acad Sci U S A. 121: e2312306120 (2023) doi: 10.1073/pnas.2312306120.

Pubmed

Shima T, Ogura M, Matsuda R, Nakamura S, Jin N, Yoshimori T, Kuma A.

The TMEM192-mKeima probe specifically assays lysophagy and reveals its initial steps. J Cell Biol. 222: e202204048 (2023) doi: 10.1083/jcb.202204048.

PubMed

Ogura M, Kaminishi T, Shima T, Torigata M, Bekku N, Tabata K, Minami S, Nishino K, Nezu A, Hamasaki M, Kosako H, Yoshimori T, Nakamura S.

Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.

EMBO Rep. 24 :e57300 (2023) . doi: 10.15252/embr.202357300.

PubMed

Shioda T, Takahashi I, Ikenaka K, Fujita N, Kanki T, Oka T, Mochizuki H, Antebi A, Yoshimori T, Nakamura S.

Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity. Proc. Natl. Acad. Sci. U. S. A. 120: e2221553120 (2023) doi: 10.1073/pnas.2221553120

PubMed

Tsai CY, Sakakibara S, Kuan YD, Omori H, El Hussien MA, Okuzaki D, Lu SL, Noda T, Tabata K, Nakamura S, Yoshimori T, Kikutani H.

Opposing roles of RUBCN isoforms in autophagy and memory B cell generation. Sci Signal. 16: eade3599. doi: 10.1126/scisignal.ade3599.

PubMed

Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, Matsui S, Matsui I, Hamano T, Takahashi M, Goto M, Izumi Y, Bamba T, Sasai M, Yamamoto M, Matsusaka T, Niimura F, Yanagita M, Nakamura S, Yoshimori T, Ballabio A, Isaka Y.

TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney. JCI Insight. 8: e162498 (2023) doi: 10.1172/jci.insight.162498.

PubMed

原著論文

Tabata K, Imai K, Fukuda K, Yamamoto K, Kunugi H, Fujita T, Kaminishi T, Tischer C, Neumann B, Reither S, Verissimo F, Pepperkok R, Yoshimori T, Hamasaki M.

Yanagawa K, Kuma A, Hamasaki M, Kita S, Yamamuro T, Nishino K, Nakamura S, Omori H, Kaminishi T, Oikawa S, Kato Y, Edahiro R, Kawagoe R, Taniguchi T, Tanaka Y, Shima T, Tabata K, Iwatani M, Bekku N, Hanayama R, Okada Y, Akimoto T, Kosako H, Takahashi A, Shimomura I, Sakata Y, Yoshimori T.

Kitta S, Kaminishi T, Higashi M, Shima T, Nishino K, Nakamura N, Kosako H, Yoshimori T*, Kuma A*.

Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S.

Kakuda K, Ikenaka K, Kuma A, Doi J, Aguirre C, Wang N, Ajiki T, Choong CJ, Kimura Y, Badawy SMM, Shima T, Nakamura S, Baba K, Nagano S, Nagai Y, Yoshimori T, Mochizuki H.

Shima T, Ogura M, Matsuda R, Nakamura S, Jin N, Yoshimori T, Kuma A.

Ogura M, Kaminishi T, Shima T, Torigata M, Bekku N, Tabata K, Minami S, Nishino K, Nezu A, Hamasaki M, Kosako H, Yoshimori T, Nakamura S.

Shioda T, Takahashi I, Ikenaka K, Fujita N, Kanki T, Oka T, Mochizuki H, Antebi A, Yoshimori T, Nakamura S.

Tsai CY, Sakakibara S, Kuan YD, Omori H, El Hussien MA, Okuzaki D, Lu SL, Noda T, Tabata K, Nakamura S, Yoshimori T, Kikutani H.

Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, Matsui S, Matsui I, Hamano T, Takahashi M, Goto M, Izumi Y, Bamba T, Sasai M, Yamamoto M, Matsusaka T, Niimura F, Yanagita M, Nakamura S, Yoshimori T, Ballabio A, Isaka Y.

Kitta S, Kaminishi T, Higashi M, Shima T, Nishino K, Nakamura N, Kosako H, Yoshimori T, Kuma A.