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Choong CJ, Okuno T, Ikenaka K, Baba K, Hayakawa H, Koike M, Yokota M, Doi J, Kakuda K, Takeuchi T, Kuma A, Nakamura S, Nagai Y, Nagano S, Yoshimori T, Mochizuki H

Alternative mitochondrial quality control mediated by extracellular release., Autophagy., 10;1-13, 2020 Dec. doi: 10.1080/15548627.2020.1848130

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Nakamura S, Shigeyama S, Minami S, Shima T, Akayama S, Matsuda T, Esposito A, Napolitano G, Kuma A, Namba-Hamano T, Nakamura J, Yamamoto K, Sasai M, Tokumura A, Miyamoto M, Oe Y, Fujita T, Terawaki S, Takahashi A, Hamasaki M, Yamamoto M, Okada Y, Komatsu M, Nagai T, Takabatake Y, Xu H, Isaka Y, Ballabio A, Yoshimori T

LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury., Nat. Cell Biol., (2020), doi: 10.1038/s41556-020-00583-9

PubMed

Yamamuro T, Kawabata T, Fukuhara A, Saita S, Nakamura S, Takeshita H, Fujiwara M, Enokidani Y, Yoshida G, Tabata K, Hamasaki M, Kuma A, Yamamoto K, Shimomura I, Yoshimori T

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. Nat. Commun., 11(1):4150. (2020) Epub 2020 Aug 18. doi: 10.1038/s41467-020-17985-w.

PubMed

Murase D, Kusaka-Kikushima A, Hachiya A, Fullenkamp R, Stepp A, Imai A, Ueno M, Kawabata K, Takahashi Y, Hase T, Ohuchi A, Nakamura S, Yoshimori T

Autophagy Declines with Premature Skin Aging resulting in Dynamic Alterations in Skin Pigmentation and Epidermal Dierentiation. Int J Mol Sci., 21(16):5708. 2020 Aug 9. doi: 10.3390/ijms21165708

PubMed

Aoyama S, Nishida Y, Fujitani Y, Fukunaka A, Miyatsuka T, Suzuki L, Himuro M, Yoshimori T, Watada H

Rubicon in pancreatic beta cells plays a limited role in maintaining glucose homeostasis following increased insulin resistance., Endocr J., 2020 Jul 16. doi: 10.1507/endocrj.EJ20-0326

PubMed

Bhargava HK, Tabata K, Byck JM, Hamasaki M, Farrell DP, Anishchenko I, DiMaio F, Im YJ, Yoshimori T, Hurley JH

Structural Basis for Autophagy Inhibition by the Human Rubicon-Rab7 Complex.

Proc Natl Acad Sci U S A, 117(29):17003-17010 (2020), Epub 2020 Jul 6. doi: 10.1073/pnas.2008030117

PubMed

Yamamoto YH, Kasai A, Omori H, Takino T, Sugihara M, Umemoto T, Hamasaki M, Hatta T, Natsume T, Morimoto RI, Arai R, Waguri S, Sato M, Sato K, Bar-Nun S, Yoshimori T, Noda T, Nagata K.

ERdj8 governs the size of autophagosomes during the formation process.
J Cell Biol., 219(8):e201903127.(2020). doi: 10.1083/jcb.201903127.

PubMed

Wakita M, Takahashi A, Sano O, Loo TM, Imai Y, Narukawa M, Iwata H, Matsudaira T, Kawamoto S, Ohtani N, Yoshimori T, Hara E.

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.
Nat. Commun., 11(1):1935. (2020) Epub 2020 Apr 22. doi: 10.1038/s41467-020-15719-6.

PubMed

Ikari S, Lu SL, Hao F, Imai K, Araki Y, Yamamoto Y, Tsai CY, Nishiyama Y, Shitan N, Yoshimori T, Otomo T, Noda T.

Starvation-induced autophagy via calcium-dependent TFEB dephosphorylation is suppressed by Shigyakusan.
PLoS One. 15(3):e0230156 (2020) Epub 2020 Mar 5. doi:10.1371/journal.pone.0230156

PubMed

Matsuda J, Takahashi A, Takabatake Y, Sakai S, Minami S, Yamamoto T, Fujimura R, Namba-Hamano T, Yonishi H, Nakamura J, Kimura T, Kaimori JY, Matsui I, Takahashi M, Nakao M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Yoshimori T, Isaka Y.

Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Autophagy. 1-16 (2020) Epub 2020 Jan 16. doi: 10.1080/15548627.2020.1712107.

PubMed

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